Some people claim the newer generations of jet-liners, like the Boeing 787, will reduce jet lag because they allow higher humidity in the cabin and higher air pressure (more oxygen). In fact that was discussed right here on a TravelGumbo during an interview with Norwegian Air.
A few more points. I try not to have more than one or two connections on any flight, especially on overseas trips (for people traveling from small cities, this can be challenging). I find the fatigue factor clouds my judgement to the point where I make stupid mistakes (eg. forget something in the plane). I'll split it into two trips. For example, we spent time in New York before flying to South Africa on our trip from the West Coast.
Also, I find if there's a single night it's important to have a decent place to sleep is that first night on an overseas trip. It doesn't have to be luxurious, but a comfortable bed in a quiet room is priceless after having been squeezed into the back of the plane for hours and hours.